Dissolution improvement of high drug-loaded solid dispersion
نویسندگان
چکیده
منابع مشابه
Improvement of Dissolution Behavior of Paracetamol Using Solid Dispersion Technique
Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in ...
متن کاملSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملReview Article IMPROVEMENT OF DRUG SOLUBILITY USING SOLID DISPERSION
The solubility behaviour of drug is one of the most challenging aspects in formulation development. Thus a greater understanding of dissolution and absorption behaviour of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Therefore different approaches are being explored to enhance the solubility of poorly water so...
متن کاملDevelopment and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers
INTRODUCTION The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. METHODS Solid dispersion formulations with different carriers including crospovidone, microcrystalline cellulose, Elaeagnus angustifolia fruit powder, with different drug to carrier ratios were prepared employing cogrinding method. Dissolution st...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2006
ISSN: 1530-9932
DOI: 10.1208/pt070252